Regulatory regions
نویسندگان
چکیده
منابع مشابه
Kernels for gene regulatory regions
We describe a hierarchy of motif-based kernels for multiple alignments of biological sequences, particularly suitable to process regulatory regions of genes. The kernels incorporate progressively more information, with the most complex kernel accounting for a multiple alignment of orthologous regions, the phylogenetic tree relating the species, and the prior knowledge that relevant sequence pat...
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Efforts to understand the genetic basis of evolutionary change have concentrated on proteins and their encoding DNA sequences. These studies have brought to light patterns and processes at the nucleotide level, yet the complex functional relationships between genetic variants and phenotypes remain poorly known. The realization that even a complete description of proteins and the effects of thei...
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This paper presents implementation of Data Mining and Knowledge Discovery techniques for analysis of gene regulatory regions. The method is designed to search for regularities in tables of context features of DNA sequences involved in regulation of transcription. The goal is to discover regularities that relate nucleotide sequences to the functional classes of these sequences. The search patter...
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Products of the myc gene family integrate extracellular signals by modulating a wide range of their targets involved in cellular biogenesis and metabolism; the purpose of this integration is to regulate cell death, proliferation, and differentiation. However, understanding the regulation of myc at the transcription level remains a challenge. We performed rapid amplification of dmyc cDNA ends (5...
متن کاملTriplex-Forming Sequences in Regulatory Regions
Triplexes are formed when a triplex-forming oligonucleotide (TFO), typically a short single stranded oligonucleotide recognizes a triplex-forming sequence (TFS) in a duplex DNA by means of specific hydrogen-bond interactions between the central Watson-Crick and the third nucleobase. Two types of triplexes exist: i) parallel triplexes based on the pyrimidine motif and Hoogsteen-type recognition ...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2012
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.2432